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1

Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial

Martin A. Graham, Suresh Senan, Hernani Robin Jr., Nils Eckhardt, Dennis Lendrem, Jeffery Hincks, Dennis Greenslade, Roy Rampling, Stanley B. Kaye, Reinhard von Roemeling, Paul Workman

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1997

Language:

english

File:

PDF, 193 KB

english, 1997

2

The Therapeutic Index of Cytotoxic Chemotherapy Depends upon Circadian Drug Timing

REINHARD VON ROEMELING

Journal:

Annals of the New York Academy of Sciences

Year:

1991

File:

PDF, 1.82 MB

1991

3

Monoclonal antibody dose determination and biodistribution into solid tumors

Beckman, Robert A, von Roemeling, Reinhard, Scott, Andrew M

Journal:

Therapeutic Delivery

Year:

2011

Language:

english

File:

PDF, 907 KB

english, 2011

4

MR imaging of patients with implanted drug infusion pumps

Reinhard Von Roemeling, Rosellen M. Lanning, Frederick A. Eames

Journal:

Journal of Magnetic Resonance Imaging

Year:

1991

Language:

english

File:

PDF, 516 KB

english, 1991

5

52 Clinical evaluation of the hypoxic cytotoxin tirapazamine (SR-4233): Phase I experience with repeated dose administration during fractionated irradiation

Steven L. Hancock, Sharon Spencer, Carol Mariscal, Ann Wooten, Richard Wheeler, J. Martin Brown, Cheryl Fisher, Reinhard Von Roemeling

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1996

Language:

english

File:

PDF, 139 KB

english, 1996

6

87 A phase II trial of radiotherapy with concurrent tirapazamine, a hypoxic cytotoxin, for advanced head and neck carcinomas

Ding-Jen Lee, Andy Trotti, Sharon Spencer, Robert Rostock, Cheryl Fisher, Reinhart von Roemeling, Eric Groves

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1996

Language:

english

File:

PDF, 114 KB

english, 1996

7

Concurrent tirapazamine and radiotherapy for advanced head and neck carcinomas: a phase II study

Ding-Jen Lee, Andy Trotti, Sharon Spencer, Robert Rostock, Cheryl Fisher, Reinhard von Roemeling, Elizabeth Harvey, Eric Groves

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1998

Language:

english

File:

PDF, 51 KB

english, 1998

8

Phase I trial of the hypoxic cell cytotoxin tirapazamine with concurrent radiation therapy in the treatment of refractory solid tumors

Lawrence N Shulman, Lori Buswell, Nancy Riese, Nancy Doherty, Jay S Loeffler, Reinhard W von Roemeling, C.Norman Coleman

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1999

Language:

english

File:

PDF, 68 KB

english, 1999

9

A phase III double-blind randomized placebo controlled study of porfiromycin and radiation therapy in patients with head and neck cancer

E.F Lartigau, J Giralt, P Glassman, A Lawton, R von Roemeling

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2002

Language:

english

File:

PDF, 20 KB

english, 2002

10

Tirapazamine-cisplatin: the synergy

Gatzemeier, U, Rodriguez, G, Treat, J, Miller, V, von Roemeling, R, Viallet, J, Rey, A

Journal:

British Journal of Cancer

Year:

1998

Language:

english

File:

PDF, 427 KB

english, 1998

11

Loss of type III transforming growth factor-β receptor expression is due to methylation silencing of the transcription factor GATA3 in renal cell carcinoma

Cooper, S J, Zou, H, LeGrand, S N, Marlow, L A, von Roemeling, C A, Radisky, D C, Wu, K J, Hempel, N, Margulis, V, Tun, H W

Journal:

Year:

2010

Language:

english

File:

PDF, 738 KB

english, 2010

12

Phase I Study of Tirapazamine and Cisplatin in Patients with Recurrent Cervical Cancer

Carol Aghajanian, Carol Brown, Catherine O'flaherty, Aaron Fleischauer, John Curtin, Reinhard von Roemeling, David R. Spriggs

Journal:

Gynecologic Oncology

Year:

1997

Language:

english

File:

PDF, 60 KB

english, 1997

13

Chronotherapy of cancer: a major drug-deliver challenge

William J.M. Hrushesky, Marek Martynowicz, Miroslaw Markiewicz, Reinhard von Roemeling, Patricia A. Wood, Salvador Sánchez de la Peña

Journal:

Advanced Drug Delivery Reviews

Year:

1992

Language:

english

File:

PDF, 5.00 MB

english, 1992

14

Comparison of Urinary Desmosine Excretion in Patients with Chronic Obstructive Pulmonary Disease or Cystic Fibrosis

DC Bode, ED Pagani, WR Cumiskey, R von Roemeling, L Hamel, PJ Silver

Journal:

Pulmonary Pharmacology & Therapeutics

Year:

2000

Language:

english

File:

PDF, 123 KB

english, 2000

15

Foxo3a drives proliferation in anaplastic thyroid carcinoma through transcriptional regulation of cyclin A1: a paradigm shift that impacts current therapeutic strategies

Marlow, L. A., von Roemeling, C. A., Cooper, S. J., Zhang, Y., Rohl, S. D., Arora, S., Gonzales, I. M., Azorsa, D. O., Reddi, H. V., Tun, H. W., Doppler, H. R., Storz, P., Smallridge, R. C., Copland,

Journal:

Journal of Cell Science

Year:

2012

Language:

english

File:

PDF, 3.03 MB

english, 2012

16

Rationale and Design of MARQUEE: A Phase III, Randomized, Double-Blind Study of Tivantinib Plus Erlotinib Versus Placebo Plus Erlotinib in Previously Treated Patients With Locally Advanced or Metastatic, Nonsquamous, Non–Small-Cell Lung Cancer

Giorgio V. Scagliotti, Silvia Novello, Joan H. Schiller, Vera Hirsh, Lecia V. Sequist, Jean-Charles Soria, Joachim von Pawel, Brian Schwartz, Reinhard Von Roemeling, Alan B. Sandler

Journal:

Clinical Lung Cancer

Year:

2012

Language:

english

File:

PDF, 332 KB

english, 2012

17

79 Phase I experience of the hypoxic cytotoxin tirapazamine using multiple dosing schedules during fractionated irradiation

S. Spencer, S. Hancock, C. Mariscal, A. Wooten, R. Wheeler, J.M. Brown, C. Fisher, R. Von Roemeling

Journal:

Radiotherapy and Oncology

Year:

1996

Language:

english

File:

PDF, 132 KB

english, 1996

18

240 Molecular imaging of Death Receptor 5 (DR5) occupancy in-vivo by humanized monoclonal antibody CS-1008

A.M. Scott, F.T. Lee, G.C. Cartwright, G.J. O'Keefe, R.A. Beckman, K. Fujiwara, R. von Roemeling

Journal:

European Journal of Cancer Supplements

Year:

2010

Language:

english

File:

PDF, 46 KB

english, 2010

19

Efatutazone, an Oral PPAR-γ Agonist, in Combination With Paclitaxel in Anaplastic Thyroid Cancer: Results of a Multicenter Phase 1 Trial

Smallridge, R. C., Copland, J. A., Brose, M. S, Wadsworth, J. T., Houvras, Y., Menefee, M. E., Bible, K. C., Shah, M. H., Gramza, A. W., Klopper, J. P., Marlow, L. A., Heckman, M. G., Von Roemeling, R

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2013

Language:

english

File:

PDF, 1.48 MB

english, 2013

20

115 Tirapazamine plus cisplatin in patients (pts) with advanced non-small cell lung cancer (NSCLC)

Ng, K., Miller, V.A., Grant, S.C., Pizzo, B., Heelan, R.T., von Roemeling, R., Kris, M.G.

Journal:

Year:

1997

Language:

english

File:

PDF, 153 KB

english, 1997

21

Intravesical Recombinant Tumor Necrosis Factor in the Treatment of Superficial Bladder Cancer: An Eastern Cooperative Oncology Group Study

Glazier, David B., Bahnson, Robert R., McLeod, David G., von Roemeling, Reinhard W., Messing, Edward M., Ernstoff, Marc S.

Journal:

The Journal of Urology

Year:

1995

Language:

english

File:

PDF, 372 KB

english, 1995

22

482 Relationship Between Tumor MET Expression and Clinical Outcomes in Cancer Patients Treated with Tivantinib

Zahir, H., Rodig, S., Sequist, L.V., Rimassa, L., Eng, C., Halim, A.B., Wang, Y., von Roemeling, R., Chen, Y., Schwartz, B.

Journal:

European Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 61 KB

english, 2012

23

Stearoyl-CoA Desaturase 1 Is a Novel Molecular Therapeutic Target for Clear Cell Renal Cell Carcinoma

von Roemeling, C. A., Marlow, L. A., Wei, J. J., Cooper, S. J., Caulfield, T. R., Wu, K., Tan, W. W., Tun, H. W., Copland, J. A.

Journal:

Clinical Cancer Research

Year:

2013

Language:

english

File:

PDF, 2.78 MB

english, 2013

24

Analysis of altered microRNA expression profile in the reparative interface of the femoral head with osteonecrosis

Yuan, Heng-feng, Von Roemeling, Christina, Gao, Hui-di, Zhang, Jing, Guo, Chang-an, Yan, Zuo-qin

Journal:

Experimental and Molecular Pathology

Year:

2015

Language:

english

File:

PDF, 2.18 MB

english, 2015

25

Neuronal Pentraxin 2 Supports Clear Cell Renal Cell Carcinoma by Activating the AMPA-Selective Glutamate Receptor-4

von Roemeling, C. A., Radisky, D. C., Marlow, L. A., Cooper, S. J., Grebe, S. K., Anastasiadis, P. Z., Tun, H. W., Copland, J. A.

Journal:

Cancer Research

Year:

2014

Language:

english

File:

PDF, 3.09 MB

english, 2014

26

Reexpression of Tumor Suppressor, sFRP1, Leads to Antitumor Synergy of Combined HDAC and Methyltransferase Inhibitors in Chemoresistant Cancers

Cooper, S. J., von Roemeling, C. A., Kang, K. H., Marlow, L. A., Grebe, S. K., Menefee, M. E., Tun, H. W., Colon-Otero, G., Perez, E. A., Copland, J. A.

Journal:

Molecular Cancer Therapeutics

Year:

2012

Language:

english

File:

PDF, 1.67 MB

english, 2012

27

Determination of the Therapeutic Index of Floxuridine by Its Circadian Infusion Pattern

von Roemeling, R., Hrushesky, W. J. M.

Journal:

JNCI Journal of the National Cancer Institute

Year:

1990

Language:

english

File:

PDF, 6.12 MB

english, 1990

28

Molecular Imaging of Death Receptor 5 Occupancy and Saturation Kinetics In Vivo by Humanized Monoclonal Antibody CS-1008

Burvenich, I. J. G., Lee, F. T., Cartwright, G. A., O'Keefe, G. J., Makris, D., Cao, D., Gong, S., Chueh, A. C., Mariadason, J. M., Brechbiel, M. W., Beckman, R. A., Fujiwara, K., von Roemeling, R., S

Journal:

Clinical Cancer Research

Year:

2013

Language:

english

File:

PDF, 980 KB

english, 2013

29

Aberrant Lipid Metabolism in Anaplastic Thyroid Carcinoma Reveals Stearoyl CoA Desaturase 1 as a Novel Therapeutic Target

von Roemeling, Christina A., Marlow, Laura A., Pinkerton, Anthony B., Crist, Angela, Miller, James, Tun, Han W., Smallridge, Robert C., Copland, John A.

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2015

Language:

english

File:

PDF, 4.07 MB

english, 2015

30

Targeting lipid metabolism for the treatment of anaplastic thyroid carcinoma

C. A. Von Roemeling, J. A. Copland

Year:

2015

Language:

english

File:

PDF, 584 KB

english, 2015

31

DDEL-10MICRONENVIRONMENTAL MODULATION IMPROVES NANOMEDICINE DELIVERY INTO BRAIN TUMORS

Kim, Betty Y.S., Chen, Yuanxin, Knight, Joshua, Von Roemeling, Christina, Qie, Yaqing, Liu, Xiujie, Yuan, Hengfeng, Jiang, Wen, Tun, Han, Wharen, Robert

Journal:

Year:

2015

Language:

english

File:

PDF, 25 KB

english, 2015

32

10.1023/a:1008219125746

Miller, V. A., Ng, K. K., Grant, S. C., Kindler, H., Pizzo, B., Heelan, R. T., von Roemeling, R., Kris, M. G.

Journal:

Annals of Oncology

Year:

1997

Language:

english

File:

PDF, 215 KB

english, 1997

33

10.1023/a:1008249232000

Bedikian, A. Y., Legha, S. S., Eton, O., Buzaid, A. C., Papadopoulos, N., Coates, S., Simmons, T., Neefe, J., von Roemeling, R.

Journal:

Annals of Oncology

Year:

1997

Language:

english

File:

PDF, 410 KB

english, 1997

34

Chemotherapie bei vorbehandeltem Morbus Hodgkin mit Lomustin, Bleomycin, Vinblastin und Dexamethason

Weiß, J., Roemeling, R. von, Peters, H.-D., Schmoll, H.-J., Diehl, V.

Journal:

DMW - Deutsche Medizinische Wochenschrift

Year:

1983

Language:

german

File:

PDF, 1.17 MB

german, 1983

35

PD-0008 * A RANDOMIZED, PLACEBO-CONTROLLED, PHASE 2 STUDY OF EFATUTAZONE MAINTENANCE THERAPY IN PATIENTS WITH ADVANCED COLORECTAL CANCER WHO HAVE ACHIEVED DISEASE CONTROL FOLLOWING FIRST-LINE CHEMOTHERAPY

Boucher, E., Davidenko, I., Hadler, D., von Roemeling, R., Aprile, G.

Journal:

Annals of Oncology

Year:

2014

Language:

english

File:

PDF, 184 KB

english, 2014

36

Phase II trial of tirapazamine (escalated dose) plus cisplatin in patients with advanced melanoma

Bedikian, A Y, Legha, S S, Buzaid, A C, Eton, O, Papadopoulos, N, McIntyre, S, Montgomery, D, von, Roemeling R

Journal:

Melanoma Research

Year:

1997

File:

PDF, 119 KB

1997

37

Breaking Down the Barriers to Precision Cancer Nanomedicine

von Roemeling, Christina, Jiang, Wen, Chan, Charles K., Weissman, Irving L., Kim, Betty Y.S.

Journal:

Trends in Biotechnology

Year:

2016

Language:

english

File:

PDF, 2.35 MB

english, 2016

38

Surface modification of nanoparticles enables selective evasion of phagocytic clearance by distinct macrophage phenotypes

Qie, Yaqing, Yuan, Hengfeng, von Roemeling, Christina A., Chen, Yuanxin, Liu, Xiujie, Shih, Kevin D., Knight, Joshua A., Tun, Han W., Wharen, Robert E., Jiang, Wen, Kim, Betty Y.S.

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.09 MB

english, 2016

39

Involvement of MicroRNA-210 Demethylation in Steroid-associated Osteonecrosis of the Femoral Head

Yuan, Heng-feng, Christina, Von Roemeling, Guo, Chang-an, Chu, Yi-wei, Liu, Rong-hua, Yan, Zuo-qin

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.04 MB

english, 2016

40

Erratum: Corrigendum: Surface modification of nanoparticles enables selective evasion of phagocytic clearance by distinct macrophage phenotypes

Qie, Yaqing, Yuan, Hengfeng, von Roemeling, Christina A., Chen, Yuanxin, Liu, Xiujie, Shih, Kevin D., Knight, Joshua A., Tun, Han W., Wharen, Robert E., Jiang, Wen, Kim, Betty Y. S.

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 119 KB

english, 2016

41

Designing nanomedicine for immuno-oncology

Jiang, Wen, von Roemeling, Christina A., Chen, Yuanxin, Qie, Yaqing, Liu, Xiujie, Chen, Jianzhu, Kim, Betty Y. S.

Journal:

Nature Biomedical Engineering

Year:

2017

Language:

english

File:

PDF, 1.13 MB

english, 2017

42

Lessons from immuno-oncology: a new era for cancer nanomedicine?

Jiang, Wen, Yuan, Hengfeng, Chan, Charles K., von Roemeling, Christina A., Yan, Zuoqin, Weissman, Irving L., Kim, Betty Y. S.

Journal:

Nature Reviews Drug Discovery

Year:

2017

Language:

english

File:

PDF, 103 KB

english, 2017

43

Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy

Yuan, Hengfeng, Jiang, Wen, von Roemeling, Christina A., Qie, Yaqing, Liu, Xiujie, Chen, Yuanxin, Wang, Yifan, Wharen, Robert E., Yun, Kyuson, Bu, Guojun, Knutson, Keith L., Kim, Betty Y. S.

Journal:

Nature Nanotechnology

Year:

2017

Language:

english

File:

PDF, 2.25 MB

english, 2017

44

Progressive Metastatic Renal Cell Carcinoma Controlled by Continuous 5-Fluoro-2-Deoxyuridine Infusion

von Roemeling, Reinhard, Rabatin, Jeffrey T., Fraley, Elwin E., Hrushesky, William J.M.

Journal:

The Journal of Urology

Year:

1988

Language:

english

File:

PDF, 142 KB

english, 1988

45

362 Priming of the Brain Tumor Microenvironment Enables Improved Nanomedicine Delivery

Chen, Yuanxin, Jiang, Wen, Qie, Yaqing, Liu, Xiujie, von Roemeling, Christina, Shih, Kevin, Wharen, Robert E., Kim, Betty Y.S.

Journal:

Year:

2016

Language:

english

File:

PDF, 68 KB

english, 2016

46

Pathway Signature and Cellular Differentiation in Clear Cell Renal Cell Carcinoma

Tun, Han W., Marlow, Laura A., von Roemeling, Christina A., Cooper, Simon J., Kreinest, Pamela, Wu, Kevin, Luxon, Bruce A., Sinha, Mala, Anastasiadis, Panos Z., Copland, John A., Creighton, Chad

Journal:

Year:

2010

Language:

english

File:

PDF, 1.38 MB

english, 2010

47

An Effective Personalized Approach to a Rare Tumor: Prolonged Survival in Metastatic Pancreatic Acinar Cell Carcinoma Based on Genetic Analysis and Cell Line Development

Armstrong, Matthew D., Von Hoff, Daniel, Barber, Bruce, Marlow, Laura A., von Roemeling, Christina, Cooper, Simon J., Travis, Patrick, Campbell, Elizabeth, Paz-Fumagalli, Ricardo, Copland, John A., Co

Journal:

Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 1.02 MB

english, 2011

48

Therapeutic Remodeling of the Tumor Microenvironment Enhances Nanoparticle Delivery

Chen, Yuanxin, Liu, Xiujie, Yuan, Hengfeng, Yang, Zhaogang, von Roemeling, Christina A., Qie, Yaqing, Zhao, Hai, Wang, Yifan, Jiang, Wen, Kim, Betty Y. S.

Journal:

Advanced Science

Year:

2019

Language:

english

File:

PDF, 2.58 MB

english, 2019

49

Pomalidomide alters pancreatic macrophage populations to generate an immune-responsive environment at precancerous and cancerous lesions

Bastea, Ligia I, Liou, Geou-Yarh, Pandey, Veethika, Fleming, Alicia K, Von Roemeling, Christina A, Doeppler, Heike, Li, Zhimin, Qiu, Yushi, Edenfield, Brandy, Copland, John A., Tun, Han W, Storz, Pete

Journal:

Cancer Research

Year:

2019

Language:

english

File:

PDF, 10.01 MB

english, 2019

50

Phase I Trial of Concurrent Tirapazamine, Cisplatin, and Radiotherapy in Patients With Advanced Head and Neck Cancer

Rischin, Danny, Peters, Lester, Hicks, Rodney, Hughes, Peter, Fisher, Richard, Hart, Rosetta, Sexton, Maree, D’Costa, Ieta, von Roemeling, Reinhard

Journal:

Journal of Clinical Oncology

Year:

2001

Language:

english

File:

PDF, 536 KB

english, 2001

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